Showing posts with label Gene Expression. Show all posts
Showing posts with label Gene Expression. Show all posts

Sunday, January 14, 2007

DJ Siamese!!!


Toady DJ was taking class... she mentioned about Siamese Cat and related stuffs, the pigmentation pattern. One thing I found quite strange. She said, if we take a Siamese Cat to polar regions, it will turn into black completely! The logic was, since the temperature sensitive melanin producing enzyme (tyrosinase) will be functioning. I thought this was a rubbish idea.

Say we took a Siamese Cat to polar region (or incubated it in low temperature). If the mutant melanin producing enzyme had to function, the temperature of individual cells or tissues has to drop and more importantly the drop in temperature should sustain for a reasonable time (since melanin itself isn't mutant, rather one of melanin producing enzymes are mutant. You need time to synthesize melanin and make it express). This is quite unrealistic. In the extremities (or peripheral regions), the temperature is low. The reason being there is relatively low blood supply to exposed surface area ratio. High surface area is responsible for high heat loss rate, low blood supply amplifies the situation (Because blood is directly involved in temperature homeostasis). Theoretically in polar region, we may expect a Siamese Cat turn into completely black, but practically rapid temperature loss will lead to coma and eventually death long before you can see this bizarre hypothetical phenomenon.

Arguing with DJ has no point, those who know her personally will surely agree with me ;) .

Monday, October 09, 2006

Expression and Interferance gets Nobel

I'm kind of late with this post. I wanted to post when the prize of Medicine or Physiology was declared, but now Chemistry Nobel is already declared. So both at once.

Medicine or Physiology got Nobel on RNAi or RNA interferance. The work is itself simply groundbraking and marvellous. You know just after the publication, you deserve Nobel prize. Details of RNAi can be found in the following links

1. For General People.
2. Advanced Information.

It was a remarkable feat for Andrew Z. Fire & Craig C. Mello, recieving within ~ 7/8 years of reporting.

The Chemistry Prize went to Roger D Kornberg son of another Nobel Laurate Arthur D Kornberg. His work was on Eukaryote gene expression and its regulation. He coined the presence of Mediators in EK gene regulation. Details can be found in the following links

1. For General People.
2. Advanced Information.

Gene expression sweeps Nobel this year, whats next???