Friday, September 22, 2006
Thursday, September 21, 2006
Folding or Misfolding???
I's thinking about protein folding... there are terms like misfolding, unfolding and folding.
Misfolding is kind of misleading term. As far as I remember in Biochem texts Misfolding refers to 3D arrangements other than native conformation. Then what's the native conformation??? You'll asnwer the conformation that's found naturally... more or less that's the prevalent concept.
I've problem in accepting the word Naturally. I think each and every protein has millions of naturally occuring confoormations... even if the sequence of amino acids is identical (after all the melieu isn't identical) . What you're referring as Misfolding today might appear to be the most abundant fold... We don't have what's going through most of the life forms.
Instead of Misfolding we should use Variations of Folding Pattern.
Human mind is like proteins also. There are lots of ideas, concepts, thoughts... and most importantly they are environment dependent. The view you're holding today might be well differnt from the view of tomorrow's you.
That's enough for explaining the Title of my Newest Blog.
Misfolding is kind of misleading term. As far as I remember in Biochem texts Misfolding refers to 3D arrangements other than native conformation. Then what's the native conformation??? You'll asnwer the conformation that's found naturally... more or less that's the prevalent concept.
I've problem in accepting the word Naturally. I think each and every protein has millions of naturally occuring confoormations... even if the sequence of amino acids is identical (after all the melieu isn't identical) . What you're referring as Misfolding today might appear to be the most abundant fold... We don't have what's going through most of the life forms.
Instead of Misfolding we should use Variations of Folding Pattern.
Human mind is like proteins also. There are lots of ideas, concepts, thoughts... and most importantly they are environment dependent. The view you're holding today might be well differnt from the view of tomorrow's you.
That's enough for explaining the Title of my Newest Blog.
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